Sedation in fMRI : An unsolved challenge
نویسنده
چکیده
There are many medications that can be utilized to sedate children undergoing fMR examinations. The most frequently used drugs are chloral hydrate, thiopenthal, phenobarbital, propofol, and fentanyl. These medications have some secondary effects on the electrical and metabolic activity of the cortex, cerebral blood flow(CBF), cerebral blood volume(CBV), and tissue oxygen extraction. These effects are of no concern in regular MRI (Magnetic Resonance Imaging), however, may have a significant contribution in fMR performed in the sedated child. Since fMRI is based on the hemodynamic and metabolic response of the brain to a given stimulus the selection of the sedation medication seems crucial. The following reviews the current knowledge regarding the relation of these drugs to these physiological parameters.
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